| Assignment | Title / Topic Question |
| PICO # 1 Rotation 1 – Family Medicine | In women with polycystic ovary syndrome, does metformin compared to combined oral contraceptive pills lead to greater improvement in menstrual regularity and insulin sensitivity? |
| PICO # 2 Rotation 2 – Emergency Medicine | In elderly patients with dementia presenting with acute altered mental status without a history of trauma, does routine CT head imaging compared to selective or no imaging improve diagnostic yield or result in a meaningful change in clinical management? |
| PICO # 3 Rotation 2 – Emergency Medicine | In hemodynamically stable middle aged adults undergoing emergency department procedural sedation for shoulder dislocation reduction, does ketamine compared with propofol result in fewer respiratory and hemodynamic adverse events while maintaining similar procedural success and recovery time? |
| PICO # 4 Rotation 3 – Ambulatory Care | In adults with uncomplicated skin and soft tissue infections following incision and drainage, how does clindamycin compared to trimethoprim-sulfamethoxazole affect clinical cure rates, recurrence, and medication-related adverse events? |
| PICO # 5 Rotation 3 – Ambulatory Care | Are second-generation antihistamines safer than first-generation antihistamines for breastfeeding women regarding infant adverse effects and milk supply? |
| PICO # 6 Rotation 3 – Ambulatory Care | In adult women presenting to urgent care with symptoms of uncomplicated cystitis, does urine dipstick testing accurately diagnose urinary tract infection compared with urine culture? |
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